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Weekly AI/ML & Biotech Digest — Sep 7 to Sep 13, 2026

Curated weekly digest of notable AI/ML and biotech developments. Flagged items are manually selected; remaining items are the week's most recent. 🧬 Biotech ★ AI-enhanced adaptive virtual screening of large libraries for ligand discovery — Ultralarge virtual screenings (ULVSs) evaluate billions of molecules for drug discovery but face cost, flexibility and scalability limits. ★ AlphaGenome Atlas: in silico mutagenesis of the entire human genome improves prioritization and interpretation of non-coding variants — This is a very interesting work from AlphaGenome Atlas Team/Google, where the authors generated all possible single nucleotide variations (in silico saturation mutagenesis (ISM)) and many indels. They then demonstrated potential application of their model in rare diseases related to non-coding mutations. ★ A landscape of sequence variants in 51 commercial antibody therapeutics — Sequence variants (SVs), unintended amino acid substitutions, represent a quality ...
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Weekly AI/ML & Biotech Digest — Aug 24 to Aug 30, 2026

Curated weekly digest of notable AI/ML and biotech developments. Flagged items are manually selected; remaining items are the week's most recent. 🧬 Biotech ★ Roche pens $2.5 billion pact for Hanmi's muscle-conserving obesity drug — Roche has entered a $2.5 billion deal to license Hanmi's early-stage muscle-conserving obesity asset, betting on a novel approach to weight loss that preserves muscle mass. (morning-news-biotech, 2026-08-26) ★ CRISPR Therapeutics reports Durability of Effects of CTX310 gene therapy at ESC Congress — CRISPR Therapeutics presented late-breaking abstract on CTX310, a CRISPR-Cas9 gene therapy targeting ANGPTL3 for familial hypercholesterolemia, with clinical update planned for August. (morning-news-biotech, 2026-08-26) ★ Ultrafast and reference-free sequence discovery in single-cell data — Abstract Knowledge of RNA sequences, expression, splicing, isoforms, structure and modifications is central for understanding and targeting cellu...
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Weekly AI/ML & Biotech Digest — Aug 31 to Sep 6, 2026

Curated weekly digest of notable AI/ML and biotech developments. Flagged items are manually selected; remaining items are the week's most recent. 🧬 Biotech ★ Human genetics across levels of biological organization — Genetic variation influences human physiology across biological scales from molecules to cells, tissues, organs and the whole organism. ★ From static structures to dynamic landscapes: cryo-EM redefines RNA biology — Recent advances in cryoEM are now transforming this landscape by enabling the visualization of RNA molecules across a broad spectrum of functionally relevant conformations at near atomic resolution (arxiv-digest, 2026-09-01) ★ Operationalizing open-ended biological discovery across single-cell representations — Projection into unseen datasets then evaluates their generalizability and phenotype association, providing a scalable screen for candidates that warrant prospective validation (arxiv-digest, 2026-09-01) ★ Learning Task-Specific Anti...
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Weekly AI/ML & Biotech Digest — Aug 17 to Aug 23, 2026

It have been quite a busy time since a recent family visiting trip. I only get a chance to read a few articles in the past week. Here is one that seems interesting. ★ Megalodon: Efficient LLM Pretraining and Inference with Unlimited Context Length — The quadratic complexity and weak length extrapolation of Transformers limits their ability to scale to long sequences, and while sub-quadratic solutions like linear attention and state space models exist, they empirically underperform Transformers in pretraining efficiency and downstream task accuracy. Another interesting article on synthetic biology, where researchers created a synthetic cell that puts user closer to building life from scratch. Here is a comment article from Science .
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Weekly AI/ML & Biotech Digest — Aug 10 to Aug 16, 2026

Curated weekly digest of notable AI/ML and biotech developments. Flagged items are manually selected; remaining items are the week's most recent. 🧬 Biotech ★ ViMax: Agentic Video Generation — Long-form video generation requires systematic narrative planning and visual consistency that current short-clip methods cannot provide. ★ Decoding intercellular activities for more than 1,000 secreted proteins ★ A light-controlled tetanus neurotoxin enables rapid and reversible synaptic inhibition in vivo ★ Alignment with experimental data improves protein generative modeling ★ Efficient evidence-based genome annotation with EviAnn — Machine-learning-based ab initio gene finders have long been central to eukaryotic genome annotation, largely because gene expression data were historically expensive and limited. ★ ClairS: a deep-learning method for long-read tumor–normal pair somatic small variant calling — Somatic variant discovery in tumors is crucial for clinical ana...
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Weekly AI/ML & Biotech Digest — Aug 3 to Aug 9, 2026

Curated weekly digest of notable AI/ML and biotech developments. Flagged items are manually selected; remaining items are the week's most recent. 🧬 Biotech ★ CAFE: A Co-folding Approach for Fragment Exploration of Allosteric and Cryptic Binding Sites — Co-folding models hold immense potential for allosteric drug discovery, but have been severely hampered by their systematic bias toward orthosteric ligand binding. ★ Decoding cancer circulating transcriptomic signatures with language models — Current liquid biopsy methods for multi-cancer detection using plasma cell-free RNA (cfRNA, short RNA fragments circulating in blood that can reflect disease states) typically rely on gene annotations, which can overlook signals from unannotated or repetitive genomic regions. ★ An expanded codebook of human transcription factor DNA-binding specificity — Abstract Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. ★ Generat...
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Weekly AI/ML & Biotech Digest — Jul 27 to Aug 2, 2026

Curated weekly digest of notable AI/ML and biotech developments. Flagged items are manually selected; remaining items are the week's most recent. 🧬 Biotech ★ A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation ★ Miniaturizing and modifying natural proteins with Raygun ★ Cellular and signalling mechanisms that regulate the blood–brain barrier — The blood-brain barrier (BBB) is a unique specialization of central nervous system (CNS) capillary endothelial cells that controls molecular traffic between the blood and the brain. ★ Structure-free, site-resolved contrastive learningextends small-molecule discovery beyond the reachof structure-based modeling — Virtual screening asks which molecules, among an enormous space of drug-like chemistry, are worth synthesizing and testing against a protein target. ★ Structure and evolution-guided design of minimal RNA-guided nucleases — The design of RNA-guid...
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